PRE-TREATMENT





Despite the low risk of complications, all potential candidates of ibogaine therapy should be be medically cleared for treatment. The typical screenings process involves the following:

  1. Medical History Intake
  2. Physical Examination
  3. Liver Panel
  4. Kidney Panel
  5. An EKG (Electrocardiogram)
Why are these tests important?

Heart-related Risks (Potential QT Interval Lengthening)
Ibogaine, like many other drugs that are metabolized by CYP2D6, may produce a lengthening of the QT interval of the heart rate. The QT interval is the section on an electrocardiogram (ECG, heart test) that indicates the time it takes for the heart’s electrical system to fire an impulse through the ventricles and then recharge itself. A prolonged QT interval may lead to a potentially fatal disorder known as Torsades de Pointes. Having an EKG before Ibogaine therapy may indicate whether there is a preexisting prolonged QT interval, and this information indicates whether you should be treated with Ibogaine or not.

If you have already been screened for therapy with Ibogaine, then you should have already submitted a copy of your ECG to me with a Doctors report. If the results of your ECG are normal and all your other test results are normal, then it may potentially be safe for you to have Ibogaine therapy. If you have any additional heart-related risk factors such as obesity, previous heart problems or surgeries, advanced age (over 50yrs old), or cardiovascular problems, I may request additional heart tests such as an Echocardiogram or 24hr Holter monitoring should the EKG show any irregularities.

Many prescription and over the counter medications and foods and other substances can prolong the QT interval by interfering with CYP2D6. Thus, all QT prolonging substances should be discontinued for at least four half-lives of that substance, prior to therapy with Ibogaine. A half-life is the time it takes for one-half of the original dose of a medication to leave the body.

Substances and medications known to potentially prolong the QT interval include: anti-arrhythmias, antibiotics, anti-cancer medications, anti-convulsion medication, antidepressants, anti-hypertensive’s, antihistamines, anti-malarial medication, anti-mania medications, anti-nausea medications, anti-psychotics, appetite suppressants, bronchodilators, catecholamine’s, cholinesterase inhibitors, decongestants, diuretics, immunosuppressant’s, muscle relaxants, opiates, sedatives, stimulants, sympathomimetics, and vasoconstrictors.

Grapefruit and Quinine (often used as flavor in tonic water) are also strong QT prolonging substances and should not be taken with or before Ibogaine.

Ibogaine Metabolism and Potential Drug Interactions
The liver breaks Ibogaine down into nor-Ibogaine through an enzyme in the liver known CYP2D6. An enzyme is a chemical in the body that breaks down food, liquids, drugs, or anything else people ingest, through a process called metabolism.

More than a quarter of all prescription drugs (including virtually all anti-depressants, beta-blockers and psychiatric medications) plus some herbs and foods are also primarily metabolized through CYP2D6. Therefore it is extremely important that no drugs that might interact negatively with Ibogaine be in the system prior to taking it.

Anyone who is taking medications (prescribed or otherwise) that may negatively interact with Ibogaine will be excluded from participating in Ibogaine therapy until I am sure the substance in question is no longer in the system.

A person may be excluded who is on any necessary long-term medication if there is no known information available on possible interactions with Ibogaine or psychoactive compounds.

If anyone is taking any kind of substance or medication that they have not already provided detailed information before treatment, please note it is crucial it be immediately disclosed. (Opiate based medications for colds and flue etc)

If you are on a substance that you wish to stop taking or taper down and stop taking, you should do so safely and with the assistance and recommendation of your physician, pharmacist/pharmacologist, psychiatrist, therapist and Ibogaine Treatment Provider. You will not be given Ibogaine until it can be determined that the substance in question is no longer in your system. I will request to speak to your doctor or psychiatrist to verify that this has been done according to their advice or recommendation. In some cases, you may be requested to provide a urine sample before taking any Ibogaine.

Ibogaine increases the potency (strength) of some licit and illicit drugs like opiates and stimulants. You will be informed of when to take your last dose of these substances before your Ibogaine therapy.

Also, if you are taking any herbs, herbal supplements, nutraceuticals (nutraceutical are products isolated or purified from foods that is generally sold in medicinal forms not usually associated with food. A nutraceutical is demonstrated to have a physiological benefit or provide protection against chronic disease), “smart drugs”, and/or any over-the-counter (OTC) drugs (such as decongestants, allergy/hay fever medications, pain relievers, sleep medications, etc,) please inform me immediately, or even better don’t use them if possible.